Raja’s (Arshad Warsi) anger has no bounds and he will hit out at the slightest provocation or even without intermittent explosive, the disorder, which the doctors call ‘Sarphira’. Dr Mukerjee (Irrfan Khan) is your perfect doctor who is clean and always does his work systematically. Then you may think what’s wrong with that? He has obsessive compulsive personality disorder. Schizophrenic Gangadhar (Rajpal Yadav) lives in the past and his mates are Nehru, Gandhi, Tilak and Patel. This guy is so busy fighting for ‘Swaraj’ and freedom that he lost his sanity. Cute Dabboo (Suresh Menon) is everybody’s pet. What if he hasn’t spoken for years, frightened all the time and if he is autistic. Dr Sonali (Juhi Chawla) treats all of them and she has hopes, that all they need is little time and lots of patience to get normal. But is Krazzy 4 ready for becoming normal again. Watch out the Krazzy 4 they are coming your way, and if you think they are crazy, think again!